SCMR/ISMRM Workshop

 

SCMR/ISMRM Co-Provided Workshop

January 27-28, 2016
Hyatt Regency Century Plaza
Los Angeles, California

Quantitative CMR: From Technique Development to Practical Implementation

The purpose of this workshop is to bring together basic and clinical researchers to discuss the wide range of Quantitative Cardiovascular Magnetic Resonance (CMR) Techniques and where they all stand in terms of their application in clinical research and/or clinical practice.  A major strength of CMR lies in its ability to non-invasively provide quantitative measures of many different parameters.  There are, however, still many challenges requiring improvements to the methods of acquisition and analysis, which can only be overcome by a collaborative effort of scientists, engineers and clinicians.  We have a diverse program which ranges from techniques far from clinical application to those used in routine practice and those used more for clinical research and trials.  The methods of analysis and needs for standardization are also addressed. We are delighted to have a group of excellent speakers including both leaders and younger rising stars in the field. We believe that the multi-disciplinary faculty and range of topics will benefit all participants to advance the field of quantitative CMR.

Matthias Stuber & David Firmin

 

 

SCMR/ISMRM 2016 Co-Provided Workshop Agenda
Final Program PDF - 
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Presented by the SCMR and the ISMRM Cardiac MR and Flow & Motion Study Groups

Day 1: Wednesday, January 27

8:30 am Welcome 

Matthias Stuber, PhD (University of Lausanne, Switzerland) 

David Firmin, PhD (Royal Brompton Hospital & Imperial College London, UK) 

8:35 am – 9:30 am Plenary Session 

Moderators: Matthias Stuber, PhD (University of Lausanne) 
David Firmin, PhD (Royal Brompton Hospital & Imperial College London, UK)  

8:35 am Plenary 1: Quantitative Techniques on the Horizon

Sebastian Kozerke, PhD  (Institute for Biomedical Engineering University and ETH Zurich)

At the conclusion of this presentation, participants will be better able to: 

  • Describe the structure & function of the heart at different scales
  • Understand the potential & challenges of quantitative imaging approaches 
  • Assess the potential value of microstructural and metabolic imaging and spectroscopy 

9:00 am Plenary 2:  CMR Quantification in Clincal Research & Diagnosis 

Raymond Kwong, MD, MPH (Brigham and Women's Hospital)

At the conclusion of this presentation, participants will be better able to: 

  • Appreciate the different methods used in clinical research and diagnosis
  • Understand the clinical importance of quantification to CMR
  • Describe the strengths and weaknesses of the different methods

9:25 am Q & A 

9:30 am – 10:00 am Refreshment Break

10:00 am – 12:00 pm Session 1 - Preclinical and Translational Techniques
Moderators: Sonia Nielles-Vallespin (National Institutes of Health, USA), Damian Tyler (University of Oxford, UK) 

At the conclusion of this session, participants will be better able to: 

  • Have an overview of  preclinical and translational techniques
  • Appreciate how far these techniques are from translation
  • Better understand how CMR can probe metabolism and microstructure

10:00 am Cardiac Spectroscopy

10:15 am DNP

10:30 am cDTI

10:45 am Invited Abstract Presentations 

10:45 am W 01 - Cardiac MR Fingerprinting for T1 and T2 Mapping in Four Heartbeats (Hamilton, Jesse)

11:00 am W 02 - Fast, Heart-Rate Independent, Whole-Heart, Free-Breathing, Three-Dimensional Myocardial BOLD MRI at 3T with Simultaneous 13N-Ammonia PET Validation in Canines (Yang, Hsin-Jung)

11:15 am W 03 - Detection of Increased Coronary Microvascular Permeability with MRI T1 mapping and Gadolinium-labeled Albumin (Cui, Sophia)

11:30 am W 04 - Automated Removal of Gradient-Induced Voltages From 12-Lead ECG Traces During High-Gradient Duty-Cycle MRI Sequences (Dabaghyan, Mikayel)

11:45 am Panel Discussion 

12:00 pm – 1:00 pm Lunch (On Own)

1:00 pm – 3:00 pm Session 2:  Clinical Research Approaches  
Moderators: Allison Hays, MD (Johns Hopkins Hospital, USA) , Jenny Keegan, PhD (Royal Brompton Hospital, London, UK)

At the conclusion of this session, participants will be better able to: 

  • Understand how quantitative myocardial perfusion analysis is performed and the potential benefits for clinical and research studies.
  • Understand the current and potential applications of 4D flow
  • Understand approaches to the CMR assessment of diastolic dysfunction and the clinical and research applications of cardiac strain imaging

1:00 pm Perfusion Quantification

1:15 pm 4D Flow

1:30 pm Strain CMR: techniques an applications

1:45 pm Invited Abstract Presentations 

1:45 pm W 05 - Black-Blood T1 Mapping at 3T: Reduced Partial-Voluming using Adiabatic MSDE Preparation (Weingaertner, Sebastian)

2:00 pm W 06 - An Efficient Fat Suppression Technique for Stimulated-Echo Based CMR (Ibrahim, El-Sayed)

2:15 pm W 07 - Characterization of Both Myocardial Extracellular Volume Expansion and Myocyte Mypertrophy by CMR Detect Early Signs of Myocardial Tissue Remodeling in Friedreich’s Ataxia Patients Without Heart Failure. (Coelho-Filho, Otavio)

2:30 pm W 08  - Inline Quantitative Myocardial Perfusion Flow Mapping (Xue, Hui)

2:45 pm Panel Discussion

3:00 pm – 3:30 pm Refreshment

3:30 pm – 5:30 pm Session 3 -  Techniques used in routine practice
Moderators: Philipp Beerbaum, MD (Hannover Medical University, Germany), Jonathan Weinsaft, MD (Cornell University, USA)

At the conclusion of this session, participants will be better able to:

  • Have a comprehensive overview of quantification in routine CMR
  • Describe the strengths and weaknesses of the different measurements
  • Understand the limitations of quantitative CMR in routine practice

3:30 pm Left and Right Ventricular Function 

3:45 pm 2D Flow/Velocity measurement & Valves 

4:00 pm Myocardial LGE Quantification 

4:15 pm Myocardial T1, T2 and T2* Quantification 

4:30 pm Invited Abstract Presentations 

4:30 pm W 09 - A Novel Analytical Approach to Quantitative Myocardial Edema Imaging in Acute Myocarditis Using T2-Mapping (Baessler, Bettina)

4:45 pm W 10 - In-Vivo Carotid T2 Mapping Can Accurately Quantify Plaque Lipid Content to Discriminate Between Symptomatic and Asymptomatic Patients: Histological Validation, Scan-Rescan Reproducibility and Clinical Study (Biasiolli, Luca)

5:15 pm W 11 - A Preliminary Investigation towards Automated Computation of Multiparametric Strain Z-Score in Dilated Cardiomyopathy using Navigator-gated Spiral DENSE MRI and Radial Point Interpolation Method (Kar, Julia)

5:15 pm Panel Discussion 

5:30 pm Poster Session and Reception

 

Day 2: Thursday, January 28

8:30 am Welcome 

Matthias Stuber, PhD (University of Lausanne, Switzerland
David Firmin, PhD (Royal Brompton Hospital & Imperial College London, UK

8:35 am Plenary 3: Quantification in Trials, Analysis & Standardisation 

Sven Plein, MD, PhD (University of Leeds)

At the conclusion of this presentation, participants will be better able to: 

  • Understand the importance of quantitative endpoints in clinical trials 
  • Appreciate the challenges of defining quantitative endpoints for trials including standardisation
  • Have an understanding of the value of MRI relative to other endpoints in clinical trials

9:00 am – 11:00 am Session 4:  Quantitative CMR Methods in Trials of Medical Intervention 
Moderators: Marcus Carlsson (Lund University, Sweden), Sam Nazarian (Johns Hopkins University, USA)

At the conclusion of this session, participants will be better able to: 

  • Understand the pathophysiology and prognostic implications of area at risk, salvage, microvascular obstruction and haemorrhage in myocardial infarction.
  • Know how to quantify these measures using CMR and understand the benefits and caveats of these measures and have an insight into how they have been used in randomized controlled clinical trials.
  • Understand how CMR can contribute to interventional electrophysiology trials

9:00 am AAR and Salvage 

9:15 am Microvascular Obstruction and Hemorrhage 

9:30 am CMR Parameters to Guide EP Interventions 

9:45 am Invited Abstract Presentations 

9:45 am W 12 - Two RR Myocardial Perfusion Acquisition achieves unbiased Myocardial Blood Flow (MBF) Estimates (Xue, Hui) 

10:00 am W 13 - Assessment of T1Rho Relaxation Times After Reperfused Myocardial Infarction (Witschey, Walter)

10:15 am W 14 - A T1 and ECV Phantom for Global T1 Mapping Quality Assurance: The T1 Mapping and ECV Standardisation in CMR (T1MES) Program (Captur, Gaby)

10:30 am W 15 - Pressure Gradient Measurement Using Phase Contrast (PC)-MRI in Stenotic Phantom Models: Towards Noninvasive Quantification of Fractional Flow Reserve in the Coronary Arteries (Deng, Zixin)

10:45 am Panel Discussion

11:00 am – 11:30 am Refreshment Break 

11:30 am – 12:45 pm Session 5 – Quantitative CMR Analysis and Standardisation  
Moderators: Michael Salerno, MD, PhD (University of Virginia, USA), Tobias Schaeffter, PhD (Physikalisch-Technische Bundesanstalt, PTB, Germany

At the conclusion of this presentation, participants will be better able to: 

  • Understand the importance of phantoms and comparable analysis algorithms to perform clinical multi-centre studies
  • Understand the need for physical standards (phantoms) for traceability of cross-platform measurements
  • Understand the need for comparative studies of different analysis algorithms using common datasets

11:30 am Clinical Need for Standards in CMR-Acquisition and Data Analysis

11:45 am Developing Standards with National Institutes 

12:00 pm Comparability of Data Analysis Algorithms 

12:15 pm Moderated Panel Discussion 

12:45 pm Adjourn